Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

T Chaumette; R Cinotti; A Molle; P Solomon; L Castain; C Fourgeux; HEG McWilliam; B Misme-Aucouturier; A Broquet; C Jacqueline; M Vourc’h; D Fradin; C Bossard; L David; E Montassier; C Braudeau; R Josien; JA Villadangos; K Asehnoune; C Bressollette-Bodin; J Poschmann; A Roquilly

Journal article

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

T Chaumette, R Cinotti, A Molle, P Solomon, L Castain, C Fourgeux, HEG McWilliam, B Misme-Aucouturier, A Broquet, C Jacqueline, M Vourc’h, D Fradin, C Bossard, L David, E Montassier, C Braudeau, R Josien, JA Villadangos, K Asehnoune, C Bressollette-Bodin Show all

American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2022

DOI: 10.1164/rccm.202110-2324OC

Abstract

Rationale: Brain injury induces systemic immunosuppression, increasing the risk of viral reactivations and altering neurological recovery. Objectives: To determine if systemic immune alterations and lung replication of herpesviridae are associated and can help predict outcomes after brain injury. Methods: We collected peripheral blood mononuclear cells in patients with severe brain injury requiring invasive mechanical ventilation. We systematically searched for respiratory herpes simplex virus (HSV) replications in tracheal aspirates. We also performed chromatin immunoprecipitation sequencing, RNA-sequencing, and in vitro functional assays of monocytes and CD4 T cells collected on Day 1 to c..

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University of Melbourne Researchers

Hamish McWilliam Author

Jose Villadangos Author

Antoine Roquilly Author

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ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

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Grants

Awarded by Citrus Research Board

Funding Acknowledgements

Supported by the European Commission Horizon 2020 Research and Innovation Program under grant agreement number 847782 and the Agence National de la Recherche (ANR) PROGRAM project and the CHU Nantes (Appel d'offre interne) (A.R.). J.A.V. is supported by a Principal Research Fellowship (1154502), a program grant (1113293), and a project grant (1163090) from the National Health and Medical Research Council (NHMRC) of Australia. H.E.G.M. is supported by an NHMRC Ideas Grant (2003192). J.P. is supported by Etoiles Montantes region pays de la Loire grant Epicellome.